- Vacuum Bottles & Containers, Spartanburg
- Vacuum Cleaner Repair & Service, Spartanburg
- Vacuum Cleaners, Spartanburg
- Varied Menu Restaurants, Spartanburg
- Variety Stores, Spartanburg - Wholesale Merchandise
- Vascular Surgeons, Spartanburg - Blood Vessel Surgeons, Doctors & Physicians (Vascular Surgery)
- Vehicle & Trailer Storage, Spartanburg - Auto & Truck
- Vending Machines, Spartanburg
- Vending Machines, Spartanburg
- Venture Capital Firms, Spartanburg
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- Veterans & Military Organizations, Spartanburg
- Veterans Affairs (Except Health & Insurance), Spartanburg
- Veterinarians, Spartanburg - Veterinary Services
- Veterinarians Emergency Medicine, Spartanburg - Emergency Services
- Victory Church, Spartanburg
- Video Games Arcades, Spartanburg
- Video Tapes, DVDs & Video Games - Rental & Sales, Spartanburg
- Vinyl Flooring, Spartanburg
- Vitamin, Supplements, Herbs, Diet & Health Food Stores, Spartanburg
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