- U-Haul Truck Rental, Spartanburg - U-Haul Moving
- U-Haul Trucks, Spartanburg - Uhaul Truck Rental
- U.S. Postal Service, Spartanburg
- Unfurnished Apartments, Spartanburg
- Uniforms, Spartanburg
- Uniforms, Work Clothes & Safety Clothing, Spartanburg
- Unitarian Universalist Churches, Spartanburg
- Universal Church, Spartanburg
- Unsupported Plastic Film & Sheet Manufacturers, Spartanburg
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- Upholsterers Supplies & Equipment, Spartanburg
- Upholstery Fabric Stores , Spartanburg
- Urologists, Spartanburg - Urology Doctors, Physicians & Surgeons
- Used Book Stores, Spartanburg - New & Rare Books
- Used Cars, Truck, Van & SUV Car Dealerships, Spartanburg
- Used Merchandise, Resale Shops & Thrift Stores, Spartanburg
- Utilities, Spartanburg
- Utilities Contractors, Spartanburg
- Utility Installation Contractors, Spartanburg
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