- Dance Companies, Orangeburg
- Day Spas, Orangeburg
- Decorating & Designing Services, Orangeburg
- Delicatessen Restaurants, Orangeburg
- Deliverance Church, Orangeburg
- Dentists, Orangeburg
- Department Stores, Orangeburg
- Dermatologists, Orangeburg - Skin Doctors, Physicians & Surgeons (Dermatology)
- Dialysis Clinics, Orangeburg - Kidney Dialysis Centers
- Diamonds & Precious & Semi-Precious Stones, Orangeburg
- Diner Restaurants, Orangeburg
- Direct Mail Advertising Services, Orangeburg
- Discount Stores, Orangeburg - Clothing, Grocery, Furniture, Etc
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- Dispensing Machines, Orangeburg
- Divorce & Family Law Attorneys & Lawyers, Orangeburg
- Doctorate Degree, Orangeburg
- Doctors, Physicians & Surgeons, Orangeburg
- Domestic & Family Violence Hot Line, Orangeburg
- Door Glass & Mirrors, Orangeburg
- Drainage Contractors, Orangeburg - Install & Repair Drainage Systems
- Drains, Pipes & Sewage Materials, Orangeburg
- Drinking Establishments, Orangeburg
- Drugs, Pharmaceutical Products & Toiletries - Wholesale & Manufacturers, Orangeburg
- Dry Cleaning & Laundry, Orangeburg - Dry Cleaners
- Drywall, Insulation & Plaster Contractors, Orangeburg - Installation & Repair Services
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