- Safe & Vault, Gaffney
- Salvation Army, Gaffney
- Sand Gravel & Aggregate, Gaffney
- Sandwich Shop Restaurants, Gaffney
- Satellite Dish Antennas & Equipment Dealers, Gaffney
- Satellite TV Service, Gaffney
- Savings & Loan Associations, Gaffney
- Savings Banks, Gaffney
- Scholarships & Financial Aid, Gaffney
- School - Christian, Gaffney
- Scrap & Waste Materials, Gaffney
- Screen Printing, Gaffney
- Seafood Restaurants, Gaffney
- Secondary Schools, Gaffney
- Security Alarm Systems - Home & Business, Gaffney
- Security Brokers & Dealers, Gaffney
- Security Control Systems & Monitoring, Gaffney - Polygraph, Lie Detector, CCTV, Fire Sensor Equipment, Etc
- Security Guard & Patrol Service, Gaffney - Bodyguard, Guard Dogs, Etc
- Security Services, Gaffney
- Senior Citizens Centers & Meals, Gaffney
- Senior Citizens Service & Health Organizations, Gaffney
- Septic Tank Pumping & Cleaning, Gaffney - Septic Systems
- Septic Tanks & Septic Systems Contractors, Gaffney - Installation, Repair, Service, Cleaning & Pumping Septic Tanks
- Sewer & Drain Cleaning & Repair, Gaffney - Drain Cleaner & Installation Services
- Sharpening Service, Gaffney
- Sheet Metal Contractors, Gaffney - Sheet Metal Fabrication
- Sheet Metal Fabricators & Ductwork Contractors, Gaffney
- Shipping Service, Gaffney
- Shoe Store - More, Gaffney
- Shoe Stores, Gaffney - Mens, Womens & Kids Shoes
- Shopping & Shopping Services, Gaffney
- Siding Contractors, Gaffney - Vinyl Siding, Wood, Metal & Aluminum Siding Contractors - Installation & Repair
- Signs, Gaffney
- Skin Care & Cosmetology Salons, Gaffney
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- Skin Care Products & Treatments, Gaffney
- Small Engine Parts Wholesale, Gaffney
- Snacks & Desserts, Gaffney
- Social Security And Disability Attorneys & Lawyers, Gaffney
- Social Security And Disability Lawyers & Attorneys, Gaffney
- Social Security Counselors & Representatives, Gaffney
- Social Services & Welfare, Gaffney
- Social Workers & Services, Gaffney
- Societies & Foundation Associations, Gaffney
- Soup Kitchens, Gaffney
- Southern Style Restaurants, Gaffney
- Special Events & Party Supply Rental, Gaffney
- Special Interest Schools Or Instruction, Gaffney
- Speciality Food Stores, Gaffney
- Specialty Animal Services, Gaffney
- Specialty Stores, Gaffney
- Speech & Hearing Specialists, Gaffney
- Sporting Goods Stores, Gaffney
- Sportswear Clothing Stores, Gaffney - Sports Clothes
- Staffing & Support Services, Gaffney
- State Government, Gaffney
- Steak House Restaurants, Gaffney
- Steel Manufacturers, Gaffney
- Stock & Bond Brokers & Dealers, Gaffney
- Stocks & Bond Brokers, Gaffney
- Submarine Sandwich Restaurants, Gaffney
- Substance Abuse Clinics, Gaffney - Alcoholism, Addiction & Drug Abuse Treatment Centers
- Surveyor Services, Gaffney - Surveying Service
- Swimming Pool, Sauna & Spa Contractors, Gaffney
- Swimming Pools Contractors, Gaffney - Install Inground - Above Ground Pools
- Swimming Pools Repair, Service, Supplies, Sale & Installation, Gaffney
- Swimming Pools Supplies, Equipment & Accessories, Gaffney
- Synthetic Resins & Rubber, Gaffney
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