- Obstetricians & Gynecologists, Gaffney - Ob-Gyn Doctors, Physicians & Surgeons (Obstetrics & Gynecology)
- Office Supplies, Equipment & Office Furniture Stores, Gaffney
- Oil & Gas Companies, Gaffney
- Oil & Petroleum Products, Gaffney - Merchant, Wholesalers, etc
- Oil Change & Lubrication, Gaffney - Auto Oil & Quick Lube
- Oncologists, Gaffney - Cancer Doctors, Physicians & Surgeons (Oncology)
- Ophthalmologists, Gaffney - Eye Doctors, Physicians & Surgeons (Ophthalmology)
- Optical Stores - Eyeglasses, Lenses & Sunglasses, Gaffney
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- Optometrists, Gaffney - Eye Doctors, Physicians & Surgeons (Optometry)
- Orthodontist, Gaffney - Teeth Straightening, Invisalign & Dental Braces
- Orthopedic & Prosthetic Appliances & Shoes, Gaffney - Orthopedic Shoes
- Other Building Materials & Supplies, Gaffney
- Outdoor Equipment & Accessories, Gaffney
- Outdoor Furniture & Patio Furniture, Gaffney - Garden Furniture Stores
- Outpatient Services, Gaffney - Outpatient Care
- Oxygen & Respiratory Equipment & Supplies, Gaffney - Oxygen Concentrator, Tank, Machine, etc
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