- Sand Gravel & Aggregate, Winnsboro
- Sandwich Shop Restaurants, Winnsboro
- Savings & Loan Associations, Winnsboro
- Savings Banks, Winnsboro
- School - Christian, Winnsboro
- Scientific & Laboratory Equipment & Instruments, Winnsboro
- Search & Rescue, Winnsboro
- Secondary Schools, Winnsboro
- Security & Surveillance System & Equipment, Winnsboro
- Security Alarm Systems - Home & Business, Winnsboro
- Security Control Systems & Monitoring, Winnsboro - Polygraph, Lie Detector, CCTV, Fire Sensor Equipment, Etc
- Security Services, Winnsboro
- Septic Tank Pumping & Cleaning, Winnsboro - Septic Systems
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- Septic Tanks & Systems, Winnsboro - Wholesale, Dealers & Suppliers
- Sheriff's Department, Winnsboro
- Shopping & Shopping Services, Winnsboro
- Small Engine Parts Wholesale, Winnsboro
- Social Services & Welfare, Winnsboro
- Societies & Foundation Associations, Winnsboro
- Special Events & Party Supply Rental, Winnsboro
- Specialty Animal Services, Winnsboro
- Specialty Communication Companies & Services, Winnsboro
- Specialty Stores, Winnsboro
- Sports & Recreational Services, Winnsboro
- State Government, Winnsboro
- State Parks, Winnsboro
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