- Safe & Vault, Walterboro
- Safety Equipment & Supplies, Walterboro
- Sand Gravel & Aggregate, Walterboro
- Sandblasting, Walterboro - General Contractors
- Satellite & Cable TV Equipment & Systems, Walterboro
- Satellite Dish Antennas & Equipment Dealers, Walterboro
- Satellite TV Service, Walterboro
- Savings Banks, Walterboro
- Sawmill, Paper & Woodworking Supplies, Machinery & Equipment, Walterboro
- Scrap & Waste Materials, Walterboro
- Screen Printing, Walterboro
- Seafood Restaurants, Walterboro
- Secondary Schools, Walterboro
- Security & Surveillance System & Equipment, Walterboro
- Security Alarm Systems - Home & Business, Walterboro
- Security Brokers & Dealers, Walterboro
- Security Control Systems & Monitoring, Walterboro - Polygraph, Lie Detector, CCTV, Fire Sensor Equipment, Etc
- Security Services, Walterboro
- Senior Citizens Service & Health Organizations, Walterboro
- Septic Tank Pumping & Cleaning, Walterboro - Septic Systems
- Septic Tanks & Systems, Walterboro - Wholesale, Dealers & Suppliers
- Service & Gas Station Equipment & Services, Walterboro
- Sewer & Drain Cleaning & Repair, Walterboro - Drain Cleaner & Installation Services
- Sewing Machine Repair & Service, Walterboro
- Sheriff's Department, Walterboro
- Shirts & T-Shirts, Walterboro
- Shoe Repair Shops, Walterboro
- Shoe Stores, Walterboro - Mens, Womens & Kids Shoes
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- Shooting & Target Ranges, Walterboro
- Shopping & Shopping Services, Walterboro
- Siding Materials, Walterboro
- Signs, Walterboro
- Sleep Doctors, Walterboro - Specialists, Physicians & Surgeons (Sleep Medicine)
- Small Appliances, Walterboro
- Small Business & Office Equipment Repair Services, Walterboro
- Social Clubs & Organizations, Walterboro
- Social Services & Welfare, Walterboro
- Societies & Foundation Associations, Walterboro
- Sod & Sodding Service, Walterboro
- Southern Style Restaurants, Walterboro
- Speciality Food Stores, Walterboro
- Specialty Animal Services, Walterboro
- Specialty Communication Companies & Services, Walterboro
- Specialty Stores, Walterboro
- Speech & Hearing Specialists, Walterboro
- Sporting Goods Stores, Walterboro
- Sports Bars & Lounges, Walterboro
- Sportswear Clothing Stores, Walterboro - Sports Clothes
- Staffing & Support Services, Walterboro
- State Government, Walterboro
- Steel & Metal Goods, Walterboro - Steel Distributors
- Stocks & Bond Brokers, Walterboro
- Surgical Hospitals, Walterboro - Surgical Centers
- Surveyor Services, Walterboro - Surveying Service
- Swimming Pools Repair, Service, Supplies, Sale & Installation, Walterboro
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