- Labeling Service, Simpsonville
- Laboratories Dental, Simpsonville
- Laboratories Medical, Simpsonville
- Land Surveyor, Simpsonville - Land Surveying Services
- Landscape Contractors & Designers, Simpsonville
- Landscaping, Simpsonville
- Landscaping Materials & Supplies, Simpsonville
- Late Night Restaurants, Simpsonville
- Laundry Self Service, Simpsonville
- Lawn & Garden Equipment & Supplies, Simpsonville
- Lawn & Garden Services, Simpsonville
- Lawn & Garden Supplies & Equipment, Simpsonville
- Lawn Maintenance Services, Simpsonville
- Lawn Mowers & Power Equipment, Simpsonville
- Lawyers & Attorneys, Simpsonville
- Legal & Tax Services, Simpsonville
- Legal Documents Preparation Services, Simpsonville - Legal Forms
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- Legal Professionals, Simpsonville
- Lennox Air Conditioning, Simpsonville - Air Conditioner Contractors & Systems
- Libraries, Simpsonville
- Life Insurance, Simpsonville
- Liquor Stores, Simpsonville
- Livestock, Simpsonville
- Loans Check Cashing, Simpsonville
- Loans Personal, Simpsonville
- Loans Title Services, Simpsonville
- Local & Short Haul Trucking Companies, Simpsonville
- Locksmiths, Simpsonville - Residence, Commercial, Safe & Auto Car Locksmith
- Lodging, Simpsonville
- Lodging Services, Simpsonville
- Long Haul Trucking Companies, Simpsonville
- Lumber Companies, Simpsonville - Wholesale, Manufacturers & Suppliers
- Lutheran Church, Simpsonville
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