- Dance Companies, Simpsonville
- Darts & Dart Boards Supplies, Simpsonville
- Data Communications Service, Equipment, Supplies & Sales, Simpsonville
- Data Processing Equipment & Supplies , Simpsonville
- Data Processing Services, Simpsonville
- Data Recovery Services, Simpsonville - Hard Drive Data Recovery, etc
- Day Spas, Simpsonville
- Deck Materials, Simpsonville
- Decorating & Designing Services, Simpsonville
- Delicatessen Grocers, Simpsonville
- Denomination, Non-Denominational, Etcetera, Simpsonville
- Dental Bonding & Cosmetic Dentistry, Simpsonville - Cosmetic Dentist & Tooth Bonding
- Dentists, Simpsonville
- Dentures, Simpsonville
- Department Stores, Simpsonville
- Designers, Simpsonville
- Developmental Children Services, Simpsonville
- Diner Restaurants, Simpsonville
- Direct Mail Advertising Services, Simpsonville
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- Discount Stores, Simpsonville - Clothing, Grocery, Furniture, Etc
- Disease, Handicap & Disability Services, Organizations & Groups, Simpsonville
- Dispensing Machines, Simpsonville
- Distilled Water - Wholesale, Simpsonville
- Ditching Contractors, Simpsonville
- Doctors, Physicians & Surgeons, Simpsonville
- Dogs, Simpsonville
- Donuts, Simpsonville
- Doors & Door Frames, Simpsonville - Exterior, Interior, French, Front Entry, Patio, Storm, Garage & Sliding Glass Doors
- Drains, Pipes & Sewage Materials, Simpsonville
- Drinking Establishments, Simpsonville
- Drugs, Pharmaceutical Products & Toiletries - Wholesale & Manufacturers, Simpsonville
- Dry Cleaning & Laundry, Simpsonville - Dry Cleaners
- Dryer Vent Cleaning, Repair & Installation, Simpsonville
- Drywall Contractors, Simpsonville - Drywall Repair & Installation Services
- Drywall Equipment & Supplies, Simpsonville
- Drywall, Insulation & Plaster Contractors, Simpsonville - Installation & Repair Services
- Durable & Non Durable Goods & Products, Simpsonville
- Durable Goods & Products, Simpsonville
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