- Salvage Disposal Service, Pickens
- Sandblasting, Pickens - General Contractors
- Sandwich Shop Restaurants, Pickens
- Satellite & Cable TV Equipment & Systems Repair & Service, Pickens
- Satellite TV Service, Pickens
- Savings Banks, Pickens
- Sawmill & Planing Mills, Pickens
- Sawmill Supplies & Equipment Repair, Pickens
- Screen Houses, Pickens
- Secondary Schools, Pickens
- Security Alarm Systems - Home & Business, Pickens
- Security Brokers & Dealers, Pickens
- Security Investigative Services, Pickens
- Security Services, Pickens
- Senior Citizens Information & Services, Pickens
- Septic Tank Pumping & Cleaning, Pickens - Septic Systems
- Septic Tanks & Septic Systems Contractors, Pickens - Installation, Repair, Service, Cleaning & Pumping Septic Tanks
- Sharpening Service, Pickens
- Sheet Metal Contractors, Pickens - Sheet Metal Fabrication
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- Sheet Metal Fabricators & Ductwork Contractors, Pickens
- Sheriff's Department, Pickens
- Shopping & Shopping Services, Pickens
- Siding Contractors, Pickens - Vinyl Siding, Wood, Metal & Aluminum Siding Contractors - Installation & Repair
- Social Services & Welfare, Pickens
- Societies & Foundation Associations, Pickens
- Solar Equipment, Pickens
- Special Dies Tools Jigs & Fixtures Manufacturers, Pickens
- Specialty Animal Services, Pickens
- Specialty Stores, Pickens
- Staffing & Support Services, Pickens
- Stairs & Railings Contractors, Pickens - Metal & Wood Stairs, Spiral Staircase & Stair Railing - Installation & Repair
- Stairs, Balcony, Terrace & Steeple Contractors, Pickens
- State Government, Pickens
- State Parks, Pickens
- Stocks & Bond Brokers, Pickens
- Student Housing & Services, Pickens
- Submarine Sandwich Restaurants, Pickens
- Sweepers & Scrubbers Power, Pickens
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