- Sand Gravel & Aggregate, Lugoff
- Sandblasting, Lugoff - General Contractors
- Sandwich Shop Restaurants, Lugoff
- Scrap & Waste Materials, Lugoff
- Screen Printing, Lugoff
- Seafood Restaurants, Lugoff
- Secretarial & Court Reporting Services, Lugoff
- Security Brokers & Dealers, Lugoff
- Septic Tank Pumping & Cleaning, Lugoff - Septic Systems
- Septic Tanks & Septic Systems Contractors, Lugoff - Installation, Repair, Service, Cleaning & Pumping Septic Tanks
- Service Establishment Supplies & Equipment, Lugoff
- Sewer Construction Contractors, Lugoff - Sewer Line, Pipe Installation & Repair Services
- Sheet Metal Contractors, Lugoff - Sheet Metal Fabrication
- Sheet Metal Fabricators & Ductwork Contractors, Lugoff
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- Shirts & T-Shirts, Lugoff
- Shopping & Shopping Services, Lugoff
- Signs, Lugoff
- Social Services & Welfare, Lugoff
- Specialty Stores, Lugoff
- Sporting Goods Stores, Lugoff
- Sports Bars & Lounges, Lugoff
- Staffing & Support Services, Lugoff
- Stocks & Bond Brokers, Lugoff
- Submarine Sandwich Restaurants, Lugoff
- Surveyor Services, Lugoff - Surveying Service
- Swimming Pool, Sauna & Spa Contractors, Lugoff
- Swimming Pools Contractors, Lugoff - Install Inground - Above Ground Pools
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