- Sales & Marketing Consultant, Hardeeville
- Sand Gravel & Aggregate, Hardeeville
- Sandwich Shop Restaurants, Hardeeville
- Scrap & Waste Materials, Hardeeville
- Secondary Schools, Hardeeville
- Security Alarm Systems - Home & Business, Hardeeville
- Security Control Systems & Monitoring, Hardeeville - Polygraph, Lie Detector, CCTV, Fire Sensor Equipment, Etc
- Security Services, Hardeeville
- Senior Citizens Service & Health Organizations, Hardeeville
- Septic Tanks & Systems, Hardeeville - Wholesale, Dealers & Suppliers
- Sewer & Drain Cleaning & Repair, Hardeeville - Drain Cleaner & Installation Services
- Sewing & Yarn Stores & Supplies, Hardeeville
- Sheet Metal Contractors, Hardeeville - Sheet Metal Fabrication
- Sheet Metal Fabricators & Ductwork Contractors, Hardeeville
- Sheriff's Department, Hardeeville
- Shooting & Target Ranges, Hardeeville
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- Shopping & Shopping Services, Hardeeville
- Siding Contractors, Hardeeville - Vinyl Siding, Wood, Metal & Aluminum Siding Contractors - Installation & Repair
- Signs, Hardeeville
- Snacks & Desserts, Hardeeville
- Social Services & Welfare, Hardeeville
- Special Events & Party Supply Rental, Hardeeville
- Speciality Food Stores, Hardeeville
- Specialty Animal Services, Hardeeville
- Specialty Stores, Hardeeville
- Sporting Goods Stores, Hardeeville
- Sports Medicine, Hardeeville - Doctors, Physicians & Surgeons
- Staffing & Support Services, Hardeeville
- State Government, Hardeeville
- Steel Manufacturers, Hardeeville
- Steel Mills & Blast Furnaces, Hardeeville
- Swimming Pools Repair, Service, Supplies, Sale & Installation, Hardeeville
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