- Sandwich Shop Restaurants, Leesville
- Savings & Loan Associations, Leesville
- Savings Banks, Leesville
- Scientific & Research Professionals, Leesville
- Scrap & Waste Materials, Leesville
- Seafood Restaurants, Leesville
- Secondary Schools, Leesville
- Security Brokers & Dealers, Leesville
- Shopping & Shopping Services, Leesville
- Siding Contractors, Leesville - Vinyl Siding, Wood, Metal & Aluminum Siding Contractors - Installation & Repair
- Skating Rink & Hockey Operation Services, Leesville
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- Social Clubs & Organizations, Leesville
- Social Services & Welfare, Leesville
- Specialty Animal Services, Leesville
- Specialty Stores, Leesville
- Sporting Goods Stores, Leesville
- Staffing & Support Services, Leesville
- Steel & Metal Goods, Leesville - Steel Distributors
- Steel Manufacturers, Leesville
- Stocks & Bond Brokers, Leesville
- Submarine Sandwich Restaurants, Leesville
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