- Sandwich Shop Restaurants, Kingstree
- Satellite TV Service, Kingstree
- Savings & Loan Associations, Kingstree
- Savings Banks, Kingstree
- Sawmill & Planing Mills, Kingstree
- Sawmill Supplies & Equipment Repair, Kingstree
- Security Brokers & Dealers, Kingstree
- Senior Citizens Service & Health Organizations, Kingstree
- Shoe Stores, Kingstree - Mens, Womens & Kids Shoes
- Shopping & Shopping Services, Kingstree
- Sign Equipment & Supplies, Kingstree
- Signs, Kingstree
- Silks, Nylon & Rayon Fabrics, Kingstree
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- Sleep Disorders Treatment & Information Centers, Kingstree
- Sleep Doctors, Kingstree - Specialists, Physicians & Surgeons (Sleep Medicine)
- Snack Foods, Kingstree
- Social Services & Welfare, Kingstree
- Specialty Stores, Kingstree
- Sporting Goods Stores, Kingstree
- Staffing & Support Services, Kingstree
- State Government, Kingstree
- Steel Manufacturers, Kingstree
- Stocks & Bond Brokers, Kingstree
- Storm Doors & Windows, Kingstree
- Substance Abuse Clinics, Kingstree - Alcoholism, Addiction & Drug Abuse Treatment Centers
- Surveyor Services, Kingstree - Surveying Service
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