- Laboratories Dental, Hartsville
- Laboratories Medical, Hartsville
- Land Surveyor, Hartsville - Land Surveying Services
- Landscape Contractors & Designers, Hartsville
- Landscaping, Hartsville
- Laser Game Centers, Hartsville
- Late Night Restaurants, Hartsville
- Lawn & Garden Chemicals, Insecticides & Fertilizers, Hartsville
- Lawn & Garden Services, Hartsville
- Lawn Maintenance Services, Hartsville
- Lawyers & Attorneys, Hartsville
- Legal Professionals, Hartsville
- Libraries, Hartsville
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- Life Insurance, Hartsville
- Liquor Stores, Hartsville
- Lithographic Printing, Hartsville
- Livestock, Hartsville
- Loans Personal, Hartsville
- Locks, Hartsville
- Locksmiths, Hartsville - Residence, Commercial, Safe & Auto Car Locksmith
- Locksmiths Equipment & Supplies, Hartsville
- Lodging, Hartsville
- Long Haul Trucking Companies, Hartsville
- Lubricating Oils , Hartsville - Motor Oil
- Lumber Brokers, Hartsville
- Lutheran Church, Hartsville
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