- Sales & Marketing Consultant, Clemson
- Salvation Army, Clemson
- Sandwich Shop Restaurants, Clemson
- Satellite Dish Antennas & Equipment Dealers, Clemson
- Savings Banks, Clemson
- Seafood Restaurants, Clemson
- Security Alarm Systems - Home & Business, Clemson
- Security Brokers & Dealers, Clemson
- Security Services, Clemson
- Seminaries Educational, Clemson
- Septic Tank Pumping & Cleaning, Clemson - Septic Systems
- Sewage Plant Operation, Clemson
- Shirts & T-Shirts, Clemson
- Shoe Stores, Clemson - Mens, Womens & Kids Shoes
- Shopping & Shopping Services, Clemson
- Snacks & Desserts, Clemson
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- Social Security Counselors & Representatives, Clemson
- Social Services & Welfare, Clemson
- Societies & Foundation Associations, Clemson
- Sororities, Clemson
- Special Interest Schools Or Instruction, Clemson
- Specialty Stores, Clemson
- Sporting Goods Stores, Clemson
- Sportswear Clothing Stores, Clemson - Sports Clothes
- State Government, Clemson
- Stock & Bond Brokers & Dealers, Clemson
- Stocks & Bond Brokers, Clemson
- Student Housing & Services, Clemson
- Submarine Sandwich Restaurants, Clemson
- Substance Abuse Clinics, Clemson - Alcoholism, Addiction & Drug Abuse Treatment Centers
- Surveyor Services, Clemson - Surveying Service
- Sushi Restaurants, Clemson
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