- Salvage Yards, Blacksburg - Auto, Motorcycle, Boat, Trucks, etc
- Sand Gravel & Aggregate, Blacksburg
- Sandwich Shop Restaurants, Blacksburg
- Scrap & Waste Materials, Blacksburg
- Seafood Restaurants, Blacksburg
- Secondary Schools, Blacksburg
- Security & Surveillance System & Equipment, Blacksburg
- Septic Tank Pumping & Cleaning, Blacksburg - Septic Systems
- Sewing & Yarn Stores & Supplies, Blacksburg
- Shopping & Shopping Services, Blacksburg
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- Snacks & Desserts, Blacksburg
- Social Services & Welfare, Blacksburg
- Societies & Foundation Associations, Blacksburg
- Specialty Stores, Blacksburg
- Sporting Goods Stores, Blacksburg
- State Government, Blacksburg
- State Parks, Blacksburg
- Steak House Restaurants, Blacksburg
- Stone & Rock Quarry, Blacksburg - Gravel Pit, Shale, Granite, Limestone, Crushed Rock, etc
- Substance Abuse Clinics, Blacksburg - Alcoholism, Addiction & Drug Abuse Treatment Centers
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